Holmes, 41, is entering a new part of her life, but she doesn't regret anything.
"I always wanted adventure, and I got it," Holmes told inStyle. "And I'm still on one. In life, you're supposed to have joy, pain, loss, calm. We're not supposed to say, 'If I could go back, I would want everything joyful,' because it's not going to happen. That's life. Nobody gets off free, and you're not supposed to. Because then you're going to miss things."